Cross-sectional study evaluates urinary nitrites for guiding antibiotic treatment in urinary tract infections, suggesting reliance on patient characteristics instead.
This study of 4,724 bacteriuria cases evaluated if urinary nitrites could guide empiric therapy. Nitrites lacked sensitivity and specificity, failing to accurately distinguish gram-positive from gram-negative pathogens. Because gram-positive infections correlate with age and comorbidities, clinicians should rely on patient characteristics rather than dipstick results to guide empiric antibiotic coverage.
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Feigin et al. (2026) studied this question.
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