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April 10, 2026Reproductive and Developmental MedicineOpen Access

Endometriosis pathophysiology and biomarkers: a review of immunological, genetic, hormonal, and metabolic mechanisms

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Authors

CNChafika NadifiCHChaimaa HilaliMMModou Mamoune Mbaye

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Overview

This review investigates immune and genetic mechanisms in endometriosis, suggesting new biomarkers and therapies for effective management.

Key Points

  • Explore the multifactorial mechanisms underlying endometriosis, focusing on potential biomarkers for diagnosis and treatment.
  • Narrative review of 105 studies published from 2012 to 2025
  • Searches conducted in PubMed, Scopus, MEDLINE, and Google Scholar
  • Grouping findings into immune dysfunction, genetic factors, oxidative stress, hormonal dysregulation, and microbiota
  • Identified immune dysfunction contributes to chronic inflammation and ectopic tissue growth
  • Highlighted circulating cell-free DNA as a promising diagnostic biomarker
  • Found that microbiota influences immune responses and oxidative stress, affecting disease progression

Cite This Study

Nadifi et al. (2026) studied this question.

synapsesocial.com/papers/69d893406c1944d70ce04411https://doi.org/10.1097/rd9.0000000000000163
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epigenetics, Oxidative Stress, and the Microbiome in Endometriosis: Toward an Integrated Mechanistic Framework for Precision Medicine2026 · 1 citations
  2. 2Genetic Predisposition and Pathogenesis in Endometriosis2025 · 1 citations
  3. 3Predictive markers of endometriosis: a future perspective2026
  4. 4Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy2026 · 26 citations
  5. 5Epigenetic Landscapes of Endometriosis: From Pathogenesis to Precision Medicine2024 · 1 citations