This retrospective analysis demonstrates the link between blood indices and histologic activity in IBD, suggesting clinical utility.
Key Points
This research aims to explore the relationship between blood-based indices of inflammation, nutrition, and atherogenic risk and histologic activity in inflammatory bowel disease.
Retrospective analysis of 100 IBD patients (50 Crohn's disease and 50 ulcerative colitis) without comorbidities.
Assessment of 44 variables including nutritional, inflammatory, and atherogenic indices.
Utilization of LASSO regression and sPLS-DA for variable selection and predictive modeling.
Evaluation of the discriminative performance using ROC analysis.
LASSO analysis yielded a systemic profile linked to histologic activity, with the CONUT score being a key predictor.
ROC analysis showed AUCs of 0.93 for CD and 0.87 for UC, indicating strong predictive performance.
In multivariable regression, CONUT, SIRI, and AIP were identified as independent predictors of histologic activity in both CD and UC.