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April 10, 2026BiomedicinesOpen Access

Serum Vitamin D Levels, Systemic Inflammation, and Exacerbation Among Patients with COPD GOLD Group E

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Key result

Low vitamin D in COPD is strongly linked to more exacerbations, higher hs-CRP, and worse symptoms.

Why the study?

Vitamin D deficiency has been suggested to contribute to COPD inflammation and exacerbations, but its association with systemic inflammation and exacerbation frequency in COPD GOLD group E needed investigation.

Are low serum vitamin D levels associated with increased systemic inflammation and exacerbation frequency in patients with COPD GOLD group E?

Population

111 patients with stable COPD

Comparison

Serum 25(OH)D <50 nmol/L vs ≥50 nmol/L

Design

Cross-sectional study

Authors

ASApostolos SioutasHPHans Lennart Persson

Discussion

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Overview

Hypothesis-generating for vitamin D repletion in COPD GOLD E; prospective trials needed before clinical adoption.

Key Points

  • The study aims to explore the link between serum vitamin D levels, systemic inflammation, and exacerbation rates in COPD patients.
  • Conducted a cross-sectional study on 111 stable COPD patients.
  • Divided patients into two groups based on serum 25-hydroxyvitamin D levels (&lt;50 nmol/L vs. ≥50 nmol/L).
  • Collected data on exacerbation frequency, inflammatory markers, and spirometric lung function.
  • Patients with low vitamin D levels had significantly higher CAT scores and hs-CRP levels.
  • Those with lower vitamin D experienced more frequent exacerbations.
  • Negative correlations found between vitamin D levels and both CAT scores and hs-CRP levels.

Structured PICO

Are low serum vitamin D levels associated with increased systemic inflammation and exacerbation frequency in patients with COPD GOLD group E?

P
Population
111 patients with stable COPD GOLD group E
I
Intervention
Low serum 25-hydroxyvitamin D (25(OH)D) levels (<50 nmol/L)
C
Comparator
Higher serum 25-hydroxyvitamin D (25(OH)D) levels (≥50 nmol/L)
O
Outcome
Exacerbation frequency for the past year, inflammatory markers (hs-CRP), and symptom burden (CAT score)

In patients with COPD GOLD group E, low vitamin D levels are strongly associated with greater symptom burden, systemic inflammation, and more frequent exacerbations.

Limitations

  • Cross-sectional design prevents inferring causal relationships

Cite This Study

Sioutas et al. (2026) studied this question. Low serum vitamin D (<50 nmol/L) in COPD GOLD group E patients was strongly associated with increased exacerbation frequency (r = -0.74), elevated hs-CRP, and higher symptom burden.

synapsesocial.com/papers/69d893406c1944d70ce04548https://doi.org/10.3390/biomedicines14040833
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum Vitamin D Levels, Systemic Inflammation and Exacerbations Among Patients with COPD GOLD Group E2025
  2. 2The Association between Serum Vitamin D Deficiency and COPD Exacerbation2025
  3. 3Association of Serum Vitamin D Levels in Acute Exacerbation of COPD2025
  4. 4Vitamine D in Chronic Obstructive Pulmonary Disease Patient and Its Relation to Severity and Acute Exacerbation2025
  5. 5A study to assess the relationship between vitamin D3 levels and the risk of acute exacerbation in patients with chronic obstructive pulmonary disease2024 · 2 citations