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April 10, 2026Advanced Emergency Nursing Journal

Anaphylaxis to Antivenom in a Patient With Asymptomatic Alpha-Gal IgE Antibodies: A Case Report

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Authors

JBJason S. BryantMSMatthew D. ScottCGCharles J. Gerardo

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Overview

Case report reveals anaphylaxis after antivenom in a patient with alpha-gal antibodies, highlighting risks in endemic areas.

Key Points

  • This case report aims to highlight the risk of anaphylaxis to antivenom in patients with alpha-gal IgE antibodies.
  • Describing a case of a patient with copperhead envenomation and treatment with ANAVIP® antivenom.
  • Monitoring for adverse reactions to antivenom administration.
  • Assessing the patient's tolerance to mammalian meat and evaluating IgE antibody levels.
  • The patient experienced severe hypotensive anaphylaxis after receiving ANAVIP.
  • Despite elevated alpha-gal-specific IgE, the patient tolerated subsequent treatment with ovine Fab antivenom without complications.
  • This case illustrates the need for caution in administering antivenom to patients with alpha-gal syndrome.

Cite This Study

Bryant et al. (2026) studied this question.

synapsesocial.com/papers/69d893626c1944d70ce04585https://doi.org/10.1097/tme.0000000000000619
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Also Consider

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  1. 1Hypersensitivity reactions due to North American pit viper antivenom administration and confirmed elevation of alpha-gal IgE2024 · 8 citations
  2. 2Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose2008 · 1,516 citations