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April 10, 2026Archives of cardiovascular diseasesOpen Access

Patients implanted with a leadless pacemaker after transcatheter aortic valve implantation: Results from the MITAVI prospective study

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Key result

Post-TAVI leadless pacemakers show low complications with 38% of patients regaining complete AV conduction.

Why the study?

High-grade AV block commonly follows TAVI, and leadless pacemakers may mitigate complications associated with traditional transvenous pacemakers.

Does leadless pacemaker implantation provide safe clinical and electrical outcomes at 1 year in patients requiring pacing after transcatheter aortic valve implantation?

Comparison

Leadless pacemaker implantation

Design

Prospective multicentre cohort study

Follow-up

1 year

Authors

NLNicolas LelloucheEMEloi MarijonVAVincent Algalarrondo

Discussion

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Overview

Supports safe leadless pacemaker use after TAVI in suitable patients; extends real-world evidence but leaves open randomized trial confirmation.

Key Points

  • To assess 1-year clinical and electrical outcomes of leadless pacemaker implantation in patients after transcatheter aortic valve implantation.
  • Evaluated 102 patients undergoing TAVI and leadless pacemaker implantation from July 2019 to December 2022.
  • Conducted a prospective cohort study across four French centres.
  • Followed up patients for 1 year to assess complications and electrical variables.
  • Complication rate was low, with only one cardiac tamponade and one device migration reported.
  • At 1-year follow-up, 12% of patients experienced all-cause death and heart failure hospitalization.
  • Leadless pacemaker electrical variables significantly improved, with 38% showing complete atrioventricular conduction restoration.

Structured PICO

Does leadless pacemaker implantation provide safe clinical and electrical outcomes at 1 year in patients requiring pacing after transcatheter aortic valve implantation?

P
Population
102 patients (mean age 82 ± 9 years) from four French centres who underwent transcatheter aortic valve implantation (TAVI) for severe aortic stenosis and subsequently required pacemaker implantation.
I
Intervention
Leadless pacemaker implantation (Micra) following transcatheter aortic valve implantation.
O
Outcome
1-year clinical and electrical outcomes (including complications, all-cause death, heart failure hospitalization, and electrical variables).safety

Leadless pacemakers can be safely and effectively used in patients requiring pacing after TAVI, with low complication rates and excellent electrical performance at 1 year.

Cite This Study

Lellouche et al. (2026) studied this question. Leadless pacemakers implanted post-TAVI demonstrated low complication rates, with complete AV conduction restoration in 38% of patients and a <1% need for transvenous upgrade at 1 year.

synapsesocial.com/papers/69d893626c1944d70ce04687https://doi.org/10.1016/j.acvd.2026.02.004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Leadless pacemaker implantation versus conventional transvenous cardiac pacing early after transcatheter aortic valve replacement: a safe and relevant option?2024 · 1 citations
  2. 2Leadless pacemakers in TAVI patients with conduction disturbances: insights from a real-world analysis2025
  3. 3Outcomes of leadless pacemaker implantation after cardiac surgery and transcatheter structural valve interventions2023 · 7 citations
  4. 4Leadless vs. transvenous pacemaker strategy following transcatheter aortic valve replacement: a systematic review and meta-analysis2026
  5. 5Leadless Pacemaker Implantation, Focusing on Patients With Conduction System Disorders Post–Transcatheter Aortic Valve Replacement: A Retrospective Analysis2023 · 3 citations