Key result
Two-stage hybrid TEER and CABG with LAA closure successfully treats ACS, ischemic MR, and AF.
A two-stage hybrid strategy combining transcatheter mitral valve edge-to-edge repair with coronary artery bypass grafting and left atrial appendage closure is feasible for complex patients with multiple concurrent cardiac pathologies.
May offer alternative for complex patients with concurrent cardiac disease; extends hybrid techniques but leaves open broader validation.
We present the case of an 84-year-old man with acute coronary syndrome, ischaemic mitral regurgitation, and chronic atrial fibrillation. The patient was successfully treated using a two-stage hybrid strategy consisting of initial transcatheter mitral valve edge-to-edge repair followed by coronary artery bypass grafting with Penditure-based left atrial appendage closure.
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Uchimuro et al. (2026) studied this question. A two-stage hybrid strategy of transcatheter mitral valve repair and CABG with Penditure left atrial appendage closure successfully treated a patient with ACS, ischemic MR, and chronic AF.
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