Combined Percutaneous Left Atrial Appendage Closure and Mitral Transcatheter Edge‐to‐Edge Repair: Current Evidence and Practical Considerations

Atrial fibrillation commonly coexists with severe mitral regurgitation, complicating management by necessitating long‐term anticoagulation, with its associated bleeding risk. The combined approach of percutaneous left atrial appendage closure and mitral transcatheter edge‐to‐edge repair has been proposed as a comprehensive solution, mitigating stroke risk while addressing mitral regurgitation. This approach eliminates the need for a second procedure and lifelong oral anticoagulants. Our review provides insights into the benefits and risks of combined procedures, potentially aiding clinicians in optimizing management for these patients. Long‐term follow‐up will determine whether combining these interventions improves prognosis in high‐risk patients with atrial fibrillation.