Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure

Yinlong Zhao; Xiaolu Bao; Weiyao Xiong; Xin Wan; Qingying Yu; Teng Wang; Andrew C. H. Chang; Alian Zhang; Peng Zhang; Zhenhao Lin; Han Gao; Yangyang Liu; Ye Wang; Ching Shang; Ethan Ashley; Ming Lei; Jianyi Zhang; Junfeng Zhang; Wei Han; Alex C. Y. Chang

doi:10.1093/cvr/cvag077

Key Points

This research aims to understand the role of telomere and mitochondrial DNA signaling in heart failure progression and evaluate telomere-targeting gene therapy.
Studied telomere-mitochondrial DNA communication during heart failure progression.
Conducted proof-of-concept gene therapy targeting telomeres to assess cardiac function restoration.
Telomere-mitochondrial DNA communication plays a crucial role in heart failure progression.
Telomere-targeting gene therapy shows potential in restoring cardiac function.

Implication

Gene therapy targeting telomeres shows promise in restoring cardiac function during heart failure progression.

Abstract

Our work establishes the role of telomere-mitochondria DNA signaling during HF progression and provides proof-of-concept of telomere-targeting gene therapy to restore cardiac function.

Discussion

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69d893a86c1944d70ce049a0 https://doi.org/10.1093/cvr/cvag077

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Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure

Key Points

Implication

Abstract

Discussion

Cite This Study

Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure

Key Points

Implication

Abstract

Discussion

Cite This Study

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