What question did this study set out to answer?

This research aims to understand the role of telomere and mitochondrial DNA signaling in heart failure progression and evaluate telomere-targeting gene therapy.

April 10, 2026

Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure

Key Points

This research aims to understand the role of telomere and mitochondrial DNA signaling in heart failure progression and evaluate telomere-targeting gene therapy.
Studied telomere-mitochondrial DNA communication during heart failure progression.
Conducted proof-of-concept gene therapy targeting telomeres to assess cardiac function restoration.
Telomere-mitochondrial DNA communication plays a crucial role in heart failure progression.
Telomere-targeting gene therapy shows potential in restoring cardiac function.

Abstract

Our work establishes the role of telomere-mitochondria DNA signaling during HF progression and provides proof-of-concept of telomere-targeting gene therapy to restore cardiac function.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Cite this study

Zhao et al. (Fri,) studied this question.

synapsesocial.com/papers/69d893a86c1944d70ce049a0 — DOI: https://doi.org/10.1093/cvr/cvag077

Authors

Yinlong Zhao

Shanghai Jiao Tong University

Xiaolu Bao

Weiyao Xiong

Shanghai Jiao Tong University

Journals

Cardiovascular Research

Actions

Institutions

Stanford University

University of Alabama at Birmingham

Stanford Medicine

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion