Acute Notch signaling relates to inflammatory cytokines in children with Henoch-Schönlein purpura, indicating potential disease indicators.
The Notch signaling pathway is significantly activated during the acute phase of HSP and may participate in the immunopathological process by regulating the secretion of pro-inflammatory cytokines. The mRNA expression levels of NOTCH1 and NOTCH2 may correlate with disease severity, potentially serving as reference indicators for disease assessment.
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CHEN et al. (2026) studied this question.
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