Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 10, 2026Mini-Reviews in Medicinal Chemistry

Ferroptosis in Chronic Kidney Disease: Molecular Mechanisms andTherapeutic Targets

View Full Paper
Ask AI
Bookmark
Share

Authors

XHXinlan HuMYMin YaoYWYan Wu

Discussion

Loading...

Member takes

Overview

This review highlights ferroptosis' role in renal function decline, suggesting potential therapeutic avenues for chronic kidney disease.

Key Points

  • This review aims to summarize the role of ferroptosis in chronic kidney disease and identify therapeutic targets.
  • Reviewed molecular mechanisms associated with iron overload and lipid peroxidation
  • Evaluated the interactions with pro-fibrotic and pro-inflammatory pathways
  • Highlighted regulatory factors and small-molecule modulators targeting ferroptosis
  • Discussed potential biomarkers for diagnosis and therapy
  • Ferroptosis contributes significantly to renal function decline in chronic kidney disease.
  • Inhibitors and iron chelators offer renoprotection in experimental models.
  • Regulatory factors like TFR1 and GPX4 are involved in ferroptosis mechanisms.
  • Emerging biomarkers could serve as diagnostic or therapeutic indicators.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69d8940c6c1944d70ce04f34https://doi.org/10.2174/0113895575455316260313074030
View Full Paper
Ask AI
Bookmark
Share