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April 10, 2026Oral Health Research and Clinical EvidenceOpen Access

Hyaluronic Acid as a Therapeutic Adjunct in Impacted Mandibular Third Molar Surgery: Biological and Clinical Insights – A Narrative Review

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Authors

SRSavitha Lakshmi RaghavanRJR. JayasrikrupaaPSP Suganya

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Overview

Narrative review reveals hyaluronic acid reduces complications in third molar surgery, suggesting improved recovery.

Key Points

  • This review aims to evaluate the biological properties and clinical applications of hyaluronic acid in third molar surgery.
  • Reviewed clinical and experimental studies on hyaluronic acid's effects post-surgery
  • Evaluated HA's role in pain, swelling, trismus, and tissue healing
  • Analyzed HA's properties like biocompatibility and anti-inflammatory activity
  • Hyaluronic acid reduces pain and trismus by inhibiting inflammatory mediators
  • Promotes soft-tissue healing through angiogenesis and fibroblast activation
  • Supports bone regeneration and shows efficacy similar to corticosteroids with fewer side effects

Cite This Study

Raghavan et al. (2026) studied this question.

synapsesocial.com/papers/69d8940c6c1944d70ce05098https://doi.org/10.4103/orcl.orcl_34_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of intrasocket application of hyaluronic acid on pain, swelling, and trismus after surgical extraction of impacted mandibular third molar – A randomized control trial2026
  2. 2Therapeutic Implication of Hyaluronic Acid Gel Following Impacted Mandibular Third Molar Surgery: an Observational Study2026
  3. 3Effect of Hyaluronic Acid on Socket Healing After Lower Impacted Third Molar Tooth Extraction in 40 Dental Patients2024 · 3 citations
  4. 4Efficacy of Hyaluronic Acid in Mandibular Third Molar Surgery Performed Using Conventional Bur Technique and Piezosurgery: A Comparative Study2024 · 1 citations
  5. 5Efficacy Of Hyaluronic Acid Spray in Reducing Postoperative Pain, Swelling and Enhancing Soft Tissue Healing After Transalveolar Extraction of Endodontically Treated Mandibular Molars: A Comparative Study2025