Hypoxia-Induced microRNAs confer survival advantage in bladder cancer by fine-tuning oncogenic Pathways

Takaya Ohno; Yuki Nakajima; Yuki Yoshikawa; TAKUYA TSUJINO; Ryoichi Maenosono; Ko Nakamura; Tomoaki Takai; Taizo Uchimoto; Tatsuo Fukushima; Kazuki Nishimura; Yusuke Yano; Takuya Higashio; Tomohisa Matsunaga; Keita Nakamori; Haruhito Azuma; Teruo Inamoto

doi:10.1159/000551754

April 7, 2026Oncology

Hypoxia-Induced microRNAs confer survival advantage in bladder cancer by fine-tuning oncogenic Pathways

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Key Points

The study investigates how hypoxia-induced microRNAs affect bladder cancer in terms of survival and treatment response.
Analyzed microRNA profiles in bladder cancer samples under hypoxic conditions.
Examined the regulatory effects on HIFs and other cancer-related genes.
Assessed the impact on treatment outcomes and patient survival.
Identified a distinct microRNA profile linked to hypoxia in bladder cancer.
miRNAs were found to target key genes like AGO2 and USP10.
Hypoxia-related microRNAs may enhance survival and treatment efficacy.

Implication

This research identifies how hypoxia-induced microRNAs influence survival in bladder cancer, suggesting tailored treatment strategies.

Abstract

BC under hypoxia exhibits a specific miRNA profile targeting HIFs and cancer-related genes including AGO2 and USP10, potentially influencing treatment success and survival.

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Cite This Study

Ohno et al. (2026) studied this question.

synapsesocial.com/papers/69d8940c6c1944d70ce0509f https://doi.org/10.1159/000551754

View Full Paper

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Hypoxia-Induced microRNAs confer survival advantage in bladder cancer by fine-tuning oncogenic Pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

Hypoxia-Induced microRNAs confer survival advantage in bladder cancer by fine-tuning oncogenic Pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

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