This report demonstrates a novel method for synthesizing chiral 1,4-enynes using rhodium/copper catalysis, highlighting its broad functional-group tolerance.
Key Points
To develop a regio- and enantioselective catalytic method for synthesizing chiral 1,4-enynes from terminal alkynes and allenes.
Utilized rhodium/copper catalyst for the coupling reaction.
Employed terminal alkynes and allenes as starting materials.
Assessed the reaction yields and enantioselectivities.
Evaluated functional-group tolerance of the resulting products.
Achieved high yields in the synthesis of chiral 1,4-enynes.
Demonstrated excellent enantioselectivities in the reaction.
Showcased broad functional-group tolerance in the coupling process.