What question did this study set out to answer?

To explore the mechanisms of ferroptosis and its potential as a cancer therapy.

Ferroptosis as a Therapeutic Strategy in Cancer: From Mechanisms toClinical Applications

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This review evaluates ferroptosis as a cancer therapy, suggesting new strategies for overcoming drug resistance.

To explore the mechanisms of ferroptosis and its potential as a cancer therapy.
Analyzed preclinical and clinical studies published from 2015 to 2025.
Reviewed major scientific databases including PubMed, Scopus, and Web of Science.
Evaluated small molecules, natural compounds, and nanomedicines that affect ferroptosis.
Identified key pathways involving GPX4, SLC7A11, FSP1, and iron metabolism.
Ferroptosis enhances the efficacy of chemotherapy, radiotherapy, and immunotherapy.
Noted challenges like off-target toxicity and tumor heterogeneity that hinder therapy implementation.

Shima Mehrabadi (2026) studied this question.

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