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April 10, 2026Cell DiscoveryOpen Access

Structural basis of glucosinolate recognition and transport by plant GTR1

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Authors

RYRui YanJFJunping FanCCCheng Chi

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Overview

Demonstrates GLS transport mechanisms in Arabidopsis via GTR1, suggesting crop quality enhancement.

Key Points

  • This research aims to uncover the molecular mechanisms of glucosinolate transport by GTR1.
  • Utilized cryo-EM to obtain four distinct structures of GTR1.
  • Analyzed the interactions of GLS with GTR1's central cavity residues.
  • Investigated the role of the intracellular domain in GTR1 function.
  • Identified the four structural states of GTR1, revealing key interaction sites for GLS transport.
  • Determined the importance of the E1X1X2E2K motif for proton coupling in GTR1.
  • Showed that the ICD and central cavity residues are crucial for GLS recognition.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/69d8946e6c1944d70ce05529https://doi.org/10.1038/s41421-026-00884-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural basis of glucosinolate recognition and polyspecific transport by the glucosinolate transporter GTR12026
  2. 2Beyond defense: GTR-mediated uptake of glucosinolates drives growth and structural reprogramming in broccoli seedlings2026
  3. 3Studying Salt-Induced Shifts in Gene Expression Patterns of Glucosinolate Transporters and Glucosinolate Accumulation in Two Contrasting Brassica Species2024 · 4 citations
  4. 4Structure-function analysis of plant G-protein regulatory mechanisms identifies key Gα-RGS protein interactions2024 · 5 citations
  5. 5Cell-type–specific compartmentalization and function of the glucosinolate-myrosinase system in Arabidopsis thaliana2026 · 1 citations