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This research aims to understand how mitochondrial complex I activity impacts the effectiveness of NK cells in glioblastoma immunotherapy.

Correcting Mitochondrial Complex I Defect in Tumor-Associated Natural Killer Cells Potentiates Immunotherapy for Glioblastoma

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This research aims to understand how mitochondrial complex I activity impacts the effectiveness of NK cells in glioblastoma immunotherapy.
Multiomics profiling to assess NK cell metabolic functions
Knockout of Ndufa9 in NK cells to study its effects on function
Analysis of metabolic reprogramming and epigenetic changes in NK cells
Evaluation of resveratrol-mediated NDUFA9 activation in NK cells
Impaired mitochondrial complex I activity was found in NK cells from glioma patients.
NDUFA9 abundance correlated with better patient outcomes.
Knockout of Ndufa9 led to reduced anti-tumor efficacy and metabolic dysfunction in NK cells.
Restoration of NDUFA9 function via resveratrol improved NK cell activity against glioblastoma.

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Investigating how enhancing mitochondrial function in NK cells improves glioblastoma treatment, suggesting therapeutic potential.

Zhou et al. (2026) studied this question.

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