Development and Evaluation of an LC-MS/MS Method for Determining Paraquat and Diquat in Human Plasma: a Retrospective Study

Key Points

• This research aims to develop and validate a method for accurately measuring paraquat and diquat levels in human plasma.
• Developed an LC-MS/MS method for detection.
• Conducted a retrospective study using plasma samples.
• Assessed method sensitivity and specificity in clinical scenarios.
• Method demonstrated high sensitivity and accuracy for paraquat and diquat detection.
• Results indicate quick analysis time suitable for clinical use.

Abstract