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Observational analysis links anti-RNPC3 autoantibodies to cancer risk and skin involvement in MCTD, indicating clinical significance.
Anti-RNPC3 autoantibodies were associated with a higher frequency of SSc skin involvement in patients with MCTD. Anti-RNPC3 autoantibodies, especially in high titers, might be the markers for an increased risk of cancer in MCTD that needs to be confirmed in larger cohorts.
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Jalaledin et al. (2026) studied this question.
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