What is the clinical evidence from this study?

Study design: Review. Population: ASCVD. Intervention: HDL-C.

What question did this study set out to answer?

Examine the role of HDL-C as a marker for atheroprotection and its implications for cardiovascular disease risk.

April 10, 2026Current Opinion in LipidologyOpen Access

HDL and ASCVD: is high HDL-C protective, harmful, or simply misleading?

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Key result

High HDL-C fails as a reliable atheroprotective marker to offset established ASCVD risks.

Key Points

Examine the role of HDL-C as a marker for atheroprotection and its implications for cardiovascular disease risk.
Literature review on HDL biology and its implications for ASCVD risk
Discussion on the limitations of HDL-C as a sole indicator of health
Recommendations for prioritizing functional HDL metrics and mechanism-focused trials.
High HDL-C levels alone may not indicate reduced risk of ASCVD
Emphasis on the need for functional metrics of HDL quality
Current understanding of HDL-C requires reevaluation for therapeutic approaches.

PICO

Population

ASCVD

Exposure / Comparator

HDL-C

Implication

HDL-C is not a reliable marker of atheroprotection, highlighting the need for future research to focus on functional HDL metrics rather than simply raising HDL-C levels.

Abstract

HDL biology remains highly relevant, but HDL-C alone should not be interpreted as a reliable marker of atheroprotection or as a therapeutic target. Very high HDL-C should not be used to downplay established causal risk factors. Future research should prioritize functional HDL metrics, deeper phenotyping, and mechanism-aligned trials to determine whether improving HDL quality, rather than simply raising HDL-C, can reduce ASCVD risk.

Discussion

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Cite This Study

Parini et al. (2026) conducted a review in ASCVD. HDL-C was evaluated. High HDL-C alone should not be interpreted as a reliable marker of atheroprotection or used to downplay established causal risk factors for ASCVD.

synapsesocial.com/papers/69d895796c1944d70ce06864 https://doi.org/10.1097/mol.0000000000001041

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Implication

HDL-C is not a reliable marker of atheroprotection, highlighting the need for future research to focus on functional HDL metrics rather than simply raising HDL-C levels.

HDL and ASCVD: is high HDL-C protective, harmful, or simply misleading?

Key Points

PICO

Implication

Abstract

Discussion

Cite This Study

HDL and ASCVD: is high HDL-C protective, harmful, or simply misleading?

Key Points

PICO

Implication

Abstract

Discussion

Cite This Study

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