Why the study?
Extramedullary intracardiac expression of multiple myeloma is extremely rare and carries a worse prognosis.
Highlights a rare case of multiple myeloma relapsing as an extramedullary intracardiac atrial mass causing cardiac tamponade.
Prompts inclusion of myeloma relapse in differential for atrial masses with tamponade; hypothesis-generating for extramedullary cardiac involvement.
We present the case of a patient diagnosed with multiple myeloma in 2021 and currently undergoing second-line treatment. On admission secondary to acute cholecystitis, she presented chest pain and cardiac tamponade. Echocardiography showed pericardial effusion and deformation of the right atrial wall with infiltrating mass. A computed tomography (CT) scan was performed that reported a voluminous filling defect in the atrium. Positron emission tomography (PET) showed high fluorodeoxyglucose (FDG) metabolism in the auricular mass, as well as multiple bone lesions. Extramedullary intracardiac expression of myeloma is extremely rare, with a worse prognosis. To our knowledge, this is the fifteenth case described in the literature that initially relapsed as atrial plasmacytoma.
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González-González et al. (2026) studied this question.
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