Evaluates oxidative stress and antioxidant levels in coronary artery disease, indicating multifactorial risk factors are involved.
Background: Coronary artery disease (CAD) is a multi-factorial, possibly fatal disease -highly predictable, preventable, and treatable.Many studies have linked excess generation of reactive oxygen species (ROS) with cellular damage and CAD.No systematic studies have been conducted to evaluate the role of ROS and antioxidant status in correlation with the physical habits (smoking and alcoholism) in the development of CAD.Hence an attempt is made here to correlate the role of oxidative stress and antioxidant status in the presence of various risk factors.Materials and methods: One hundred and twenty four angiographically proved CAD patients and ninety one age-and sex-matched controls were included in this study.Detailed clinical and anthropometric data were collected using proforma.Levels of the lipid peroxidation product, Malondialdehyde (MDA), antioxidants such as Super oxide dismutase (SOD), Glutathione (GSH) and Ascorbic acid were estimated in the serum of patients.These values were compared with that of the control group.Results: A significantly high level of MDA was observed in CAD patients compared to the normal counterparts (p<0.05),whereas significantly decreased levels of SOD, GSH and ascorbic acid were observed in the study subjects.This study could not observe a significant elevation in oxidative stress and decrease in antioxidant status among smokers and/or alcoholics.Conclusion: CAD is a multifactorial disease caused by interaction of many external or internal risk factors.It is associated with greater than normal lipid peroxidation, and an imbalance in the antioxidant status.
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Simon et al. (2011) studied this question.
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