Abstract Large Language Models (LLMs) are increasingly deployed in medicine. However, their utility for non-generative clinical prediction is under-evaluated, and they are often assumed to be inferior to specialized models, creating potential for misuse and misunderstanding. To address this, our ClinicRealm benchmark systematically evaluates 15 GPT-style LLMs, 5 BERT-style models, and 11 traditional methods on unstructured clinical notes and structured Electronic Health Records (EHR) across predictive performance, reasoning, fairness, etc. Our findings reveal a significant shift: on clinical notes, leading zero-shot LLMs (e.g., DeepSeek-V3.1-Think, GPT-5) now decisively outperform finetuned BERT models. On structured EHRs, while specialized models excel with ample data, advanced LLMs demonstrate potent zero-shot capabilities, often surpassing conventional models in data-scarce settings. Notably, leading open-source LLMs match or exceed their proprietary counterparts. This provides compelling evidence that modern LLMs are competitive tools for clinical prediction, necessitating a re-evaluation of model selection strategies by health data scientists and developers.
Zhu et al. (2026) studied this question.