Key result
Unexpected cortical [18F]FP-CIT uptake reveals delayed renal cell carcinoma brain metastases, requiring anatomic imaging correlation.
Case Report (n=1)
Hypervascular metastases such as RCC may exhibit cortical [18F]FP-CIT uptake, warranting cautious interpretation and correlation with anatomic imaging.
Warrants MRI correlation for cortical FP-CIT uptake to exclude metastasis; extends known DAT imaging pitfalls to hypervascular tumors.
A 77-year-old man with a remote history of renal cell carcinoma (RCC) presented with gait disturbance and underwent delayed [18F]FP-CIT PET/CT to evaluate Parkinsonism. The scan showed focal uptake in the temporoparietal and insular cortices with a focal striatal photopenic defect. Brain MRI confirmed enhancing metastases corresponding to the cortical foci and attributed the striatal abnormality to chronic infarction. Hypervascular metastases such as RCC may exhibit cortical [18F]FP-CIT uptake, possibly from increased perfusion and/or altered blood-brain barrier permeability, reflecting nonspecific tracer retention. Therefore, cortical uptake warrants cautious interpretation and appropriate correlation with clinical history and anatomic imaging for differential diagnosis.
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Byun et al. (2026) conducted a case report in Renal cell carcinoma brain metastases (n=1). [18F]FP-CIT PET/CT was evaluated. Unexpected cortical [18F]FP-CIT uptake in a 77-year-old man revealed delayed brain metastases from renal cell carcinoma, highlighting the need for correlation with anatomic imaging.
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