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April 10, 2026Pulmonary Circulation0 citationsOpen Access

Comorbidities and Events of Clinical Interest in Patients with Pulmonary Arterial Hypertension (PAH): Analysis of Real‐World Data

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JDJulia DiBelloMerck & Co., Inc., Rahway, NJ, USA (United States)DRDena Rosen RameyMerck & Co., Inc., Rahway, NJ, USA (United States)ACAlexandra G. CornellVascular / Pulmonary Vascular

Key Points

  • To examine the prevalence of comorbidities and the incidence of clinical events in patients with pulmonary arterial hypertension.
  • Retrospective analysis of a linked claims-EHR cohort in the U.S.
  • Included 16,749 patients with pulmonary arterial hypertension.
  • Identified prevalence of hypertension, heart failure, diabetes, and chronic kidney disease.
  • Calculated incidence rates for thrombocytopenia and major bleeding.
  • Hypertension, heart failure, diabetes, and chronic kidney disease were common comorbidities.
  • Incidence rates for thrombocytopenia and major bleeding were 8.2 and 7.3 per 100 person-years, respectively.

Abstract

ABSTRACT Pulmonary arterial hypertension (PAH) patients frequently present with cardiometabolic comorbidities and experience substantial hematologic and cardiovascular events. In a retrospective U.S. linked claims‐EHR cohort ( n = 16,749), hypertension, heart failure, diabetes, and CKD were common. Incidence rates (per 100 person‐years) for thrombocytopenia and major bleeding were 8.2 and 7.3, respectively.

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Cite This Study

DiBello et al. (2026) studied this question.

synapsesocial.com/papers/69d895ea6c1944d70ce07086https://doi.org/10.1002/pul2.70288
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