Comorbidities and Events of Clinical Interest in Patients with Pulmonary Arterial Hypertension (PAH): Analysis of Real‐World Data

Julia DiBello; Dena Rosen Ramey; Alexandra G. Cornell; Harald Sinclair Mackenzie; Tammy Jiang; Michelle Skornicki; Dionna Andrean; Jackie Lucia; Ioana R. Preston

doi:10.1002/pul2.70288

April 1, 2026Pulmonary CirculationOpen Access

Comorbidities and Events of Clinical Interest in Patients with Pulmonary Arterial Hypertension (PAH): Analysis of Real‐World Data

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Key Points

To examine the prevalence of comorbidities and the incidence of clinical events in patients with pulmonary arterial hypertension.
Retrospective analysis of a linked claims-EHR cohort in the U.S.
Included 16,749 patients with pulmonary arterial hypertension.
Identified prevalence of hypertension, heart failure, diabetes, and chronic kidney disease.
Calculated incidence rates for thrombocytopenia and major bleeding.
Hypertension, heart failure, diabetes, and chronic kidney disease were common comorbidities.
Incidence rates for thrombocytopenia and major bleeding were 8.2 and 7.3 per 100 person-years, respectively.

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Implication

Analysis of real-world data shows high comorbidity rates and significant events in PAH patients, indicating urgent healthcare needs.

Abstract

Pulmonary arterial hypertension (PAH) patients frequently present with cardiometabolic comorbidities and experience substantial hematologic and cardiovascular events. In a retrospective U.S. linked claims‐EHR cohort ( n = 16,749), hypertension, heart failure, diabetes, and CKD were common. Incidence rates (per 100 person‐years) for thrombocytopenia and major bleeding were 8.2 and 7.3, respectively.

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Cite This Study

DiBello et al. (2026) studied this question.

synapsesocial.com/papers/69d895ea6c1944d70ce07086 https://doi.org/10.1002/pul2.70288

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Comorbidities and Events of Clinical Interest in Patients with Pulmonary Arterial Hypertension (PAH): Analysis of Real‐World Data

Key Points

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Implication

Abstract

Discussion

Cite This Study

Comorbidities and Events of Clinical Interest in Patients with Pulmonary Arterial Hypertension (PAH): Analysis of Real‐World Data

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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