Experimental investigation identifies microvascular rarefaction as an early event in hypertensive retinal damage, suggesting importance in monitoring.
In spontaneously hypertensive rats, superficial microvascular rarefaction and inner retinal dysfunction represent the initiating pathological events, preceding blood-retinal barrier breakdown and macrovascular remodeling. Optical coherence tomography angiography-quantified superficial vascular plexus density is a sensitive and objective imaging biomarker for assessing retinal damage during the prehypertensive stage, which significantly precedes macrovascular signs.
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Huang et al. (2026) studied this question.
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