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April 10, 2026The Journal of Sexual Medicine

Menopausal hormone therapy linked to ~48% better work ability alongside improved social and physical activity.

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Why the study?

The broader functional, social, emotional, and occupational impacts of menopause remain under-recognised and undertreated in research and clinical practice.

Does menopausal hormone therapy improve quality of life, work, relationships, social engagement, and physical activity in menopausal patients?

Population

674 new patients at a private menopause clinic in the United Kingdom

Comparison

Menopausal hormone therapy assessed at follow-up vs baseline

Design

Retrospective cohort study

Follow-up

3 months

Key result

Menopausal hormone therapy over 3 months improved social life scores (1.66 to 1.03), physical activity (1.62 to 1.01), work ability (48%), and partner relationships (49%).

Authors

HQH QuaileLNL NewsonANA Neville

Discussion

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Overview

Supports broad QoL gains with menopausal hormone therapy; extends mixed evidence but leaves causality open pending RCTs.

Key Points

  • This study aimed to evaluate menopause's impact on quality of life and changes following menopausal hormone therapy.
  • Retrospective cohort study of new patients at a menopause clinic in the UK.
  • Participants completed a menopause symptom and lifestyle impact questionnaire at baseline and 3-month follow-up.
  • The questionnaire assessed perceived impact across five domains using a Likert scale.
  • Mean impact scores improved significantly across all domains after 3 months of therapy.
  • The largest improvements were in social life and ability to exercise, with scores significantly decreasing.
  • Nearly half of respondents reported improved work ability and spousal relationships, with low proportions reporting worsening outcomes.

Structured PICO

Does menopausal hormone therapy improve quality of life, work, relationships, social engagement, and physical activity in menopausal patients?

P
Population
674 new patients attending a private menopause clinic in the United Kingdom between March and May 2025
I
Intervention
Menopausal hormone therapy (MHT)
C
Comparator
Baseline (pre-treatment)
O
Outcome
Perceived impact across five domains (ability to work, relationship with spouse/partner, relationship with family, social life, and ability to remain active/exercise) measured using a Likert scale from 0 to 3 at 3-month follow-uppatient reported

Menopausal hormone therapy is associated with broad quality-of-life benefits, including improvements in daily functioning and relationships, within 3 months of initiation.

Cite This Study

Quaile et al. (2026) studied this question. Menopausal hormone therapy over 3 months improved social life scores (1.66 to 1.03), physical activity (1.62 to 1.01), work ability (48%), and partner relationships (49%).

synapsesocial.com/papers/69d896046c1944d70ce0729bhttps://doi.org/10.1093/jsxmed/qdag063.090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1(095) Experiences of Menopause: A Social-Media Survey Exploring Quality of Life, Relationships, Mental Health, and Access to Hormone Therapy2026
  2. 2An Exploration of the Physical and Mental Health Impact among a Diverse Population in the United Kingdom Experiencing Perimenopause and Menopause (MARIE UK-WP2a)2025 · 1 citations
  3. 3Partnership as a modulator of the effects of hormone replacement therapy in menopause2026
  4. 4Prevalence of Cognitive and Mood-Related Symptoms in a Large Cohort of Perimenopausal and Menopausal Women2024 · 1 citations
  5. 5(097) More Than Hot Flushes: The Menopause2026