Findings demonstrate that TRT may enhance body composition but not significantly reduce fracture risk in older men, suggesting careful monitoring is essential.
In older men with confirmed hypogonadism, TRT may improve body composition and selected functional outcomes, but it should not be considered a disease-modifying strategy for preventing falls or fractures. Careful patient selection, assessment of baseline fracture/tendon risk, and structured monitoring are warranted, particularly in the context of evolving regulatory warnings regarding TRT use for age-related low testosterone.
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Szarpak et al. (2026) studied this question.
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