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April 10, 2026Digestive Endoscopy2 citations

Management of ERCP Failure in Malignant Biliary Obstruction: Comparative Effectiveness and Safety of EUS ‐Guided Gallbladder Drainage Versus Choledocoduodenostomy

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BMBenedetto MangiavillanoGFGianluca FranchellucciFAFrancesco Auriemma

Key Points

  • This research investigates the efficacy and safety of EUS-guided gallbladder drainage compared to choledocoduodenostomy in managing malignant biliary obstruction after failed ERCP.
  • Compared EUS-guided gallbladder drainage (EUS-GBD) and choledocoduodenostomy (EUS-CDS) outcomes in patients with malignant biliary obstruction (MDBO).
  • Assessed rates of efficacy and safety post-procedure.
  • Included patients without previous cholecystectomy and with clear cystic duct patency.
  • Both EUS-GBD and EUS-CDS showed comparable efficacy in MDBO management.
  • The safety profiles of EUS-GBD and EUS-CDS were similarly favorable.
  • EUS-GBD could be a simpler and safer alternative for suitable MDBO patients.

Abstract

In patients with MDBO after failed ERCP, EUS-GBD or EUS-CDS were comparable with similar rates of efficacy and safety. EUS-GBD could represent an easy and safe option in MDBO patients without previous cholecystectomy and with a clear patency of the cystic duct.

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Cite This Study

Mangiavillano et al. (2026) studied this question.

synapsesocial.com/papers/69d8962d6c1944d70ce076cbhttps://doi.org/10.1111/den.70145
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