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This review aims to provide a comprehensive overview of the mechanisms underlying Parkinson's disease and recent advances in therapy.

April 10, 2026Molecular BiomedicineOpen Access

Parkinson's disease: pathogenesis and therapeutic strategies

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This review outlines therapeutic strategies and pathogenesis of Parkinson's disease, suggesting the need for integrated treatments.

This review aims to provide a comprehensive overview of the mechanisms underlying Parkinson's disease and recent advances in therapy.
Systematic review of literature on Parkinson's disease pathogenesis and treatments.
Evaluation of pharmacotherapy and its limitations in treating symptoms.
Analysis of current and emerging therapeutic strategies including immunotherapies and gene therapies.
Pharmacotherapy mainly alleviates symptoms but does not halt disease progression.
Identified core pathological mechanisms include α-syn aggregation, oxidative stress, mitochondrial dysfunction, and neuroinflammation.
Emphasized the necessity for multi-target, personalized therapy approaches.

Zhang et al. (2026) studied this question.

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