Case reports reveal aggressive malignant melanoma with unusual muscle-like changes, highlighting diagnostic challenges.
Divergent differentiation in primary cutaneous malignant melanoma is a rare phenomenon that can pose a significant diagnostic challenge. We present two new cases of primary cutaneous malignant melanoma with rhabdomyosarcomatous differentiation, highlighting its aggressive nature. Thorough histological sampling and inclusion of skeletal muscle immunostains are essential for accurate diagnosis, particularly when rhabdoid morphology is identified.
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Daruish et al. (2026) studied this question.
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