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April 10, 2026Synapse

Effect of Healthy Aging on the Cytoarchitecture of Layer V Pyramidal Neurons in the Motor Cortex of Rats: A Golgi Study

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Authors

DGDavid González‐TapiaNVNallely Vázquez‐HernándezIGIgnacio González‐Burgos

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Overview

Examines neuronal changes in the motor cortex due to healthy aging, suggesting implications for motor skill decline.

Key Points

  • The study aims to investigate how healthy aging affects the structure of layer V pyramidal neurons in the motor cortex.
  • Used Golgi staining to analyze neurons in the motor cortex.
  • Compared the cytoarchitecture of young (3–4 months) and aged (22–24 months) rats.
  • Assessed dendritic arborization and spine density using the Sholl method.
  • Aged rats showed significant reductions in dendritic arborization.
  • Dendritic spine density was lower in aged animals compared to young.
  • All types of spines—thin, mushroom, stubby, and wide—were fewer in aged rats, indicating decreased synaptic capacity.

Cite This Study

González‐Tapia et al. (2026) studied this question.

synapsesocial.com/papers/69d896566c1944d70ce07b73https://doi.org/10.1002/syn.70047
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