What question did this study set out to answer?

To explore the impact of the TNFRSF1A (-135 T>C) polymorphism on radiation-induced oral mucositis and treatment outcomes in head and neck cancer patients.

April 10, 2026Head & Neck0 citations

TNFRSF1A (−135 T>C, rs767455) Polymorphism as a Predictor of Radiation Induced Oral Mucositis and Treatment Response in Locally Advanced Head and Neck Cancer Patients

View Full Paper

MKM. P. Sarath Krishnan BGBela Goyal SGSweety GuptaAll India Institute of Medical Sciences Rishikesh

Key Points

To explore the impact of the TNFRSF1A (-135 T>C) polymorphism on radiation-induced oral mucositis and treatment outcomes in head and neck cancer patients.
Analyzed the TNFRSF1A (-135 T>C) polymorphism in patients with locally advanced head and neck cancer
Assessed toxicity (oral mucositis) and treatment response in relation to genotypes
Compared outcomes based on C allele versus TT genotype
The C allele is associated with a higher risk of developing oral mucositis
Patients with the TT genotype show more favorable treatment responses
TNFRSF1A polymorphism may serve as a biomarker for personalized radiotherapy in head and neck cancer patients

Abstract

The TNFRSF1A (-135 T>C) polymorphism influences both toxicity and response in HNSCC, with the C allele predisposing to mucositis and the TT genotype predicting favorable outcomes. It represents a potential biomarker for personalized radiotherapy, meriting validation in larger cohorts.

Ask AI

Helpful

Bookmark

View Full Paper

Ask AI

Helpful

Bookmark

View Full Paper

TNFRSF1A (−135 T>C, rs767455) Polymorphism as a Predictor of Radiation Induced Oral Mucositis and Treatment Response in Locally Advanced Head and Neck Cancer Patients

Key Points

Abstract

Cite This Study

Also Consider

Also Consider