Predictors and Patterns of Recurrence After a Watchful Waiting Approach following Clinical Complete Response to Neoadjuvant Radiochemotherapy for Esophageal Cancer.
This observational study identifies recurrence patterns in esophageal cancer patients managed with a watchful waiting approach, suggesting implications for personalized treatment.
Key Points
This research aims to pinpoint independent predictors and patterns of recurrence in esophageal cancer patients undergoing a watchful waiting strategy after achieving complete response to neoadjuvant therapy.
Retrospective analysis of patients with complete response to neoadjuvant radiochemotherapy
Comprehensive staging and restaging using multiple imaging techniques
Assessment of recurrence patterns and clinical factors via multivariate regression
60% of patients experienced recurrence after a median of 202 days
Nodal-negative patients did not develop distant recurrence
Nodal-positive patients had a 26% rate of metastatic recurrence and a 16% rate of local regrowth