Association Between Different Glucocorticoids and Mortality in ICU Patients With Sepsis-related Acute Respiratory Distress Syndrome: A Retrospective cohort study from MIMIC-IV Database

Jiayang Huang; Zhikun Xu; Jiajia Huang; Jiajie Huang; Guibao Zhou; Wei Xiong; Shunyao Xu; Jun Li; YouLian Chen; Silin Liang; Linling He; Huaisheng Chen; Xia Liu; Chengying Hong

doi:10.1097/shk.0000000000002815

March 27, 2026Shock

Association Between Different Glucocorticoids and Mortality in ICU Patients With Sepsis-related Acute Respiratory Distress Syndrome: A Retrospective cohort study from MIMIC-IV Database

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Key Points

The study aims to evaluate the relationship between different glucocorticoids and mortality rates in ICU patients suffering from sepsis-related acute respiratory distress syndrome (ARDS).
Analyzed data from the MIMIC-IV database
Included patients diagnosed with sepsis-associated ARDS
Compared mortality across different glucocorticoids and dosing regimens
Methylprednisolone and dexamethasone were linked to lower mortality rates compared to hydrocortisone.
High-dose glucocorticoid therapy was associated with increased mortality.
Selection of glucocorticoid type and dosage significantly impacted patient outcomes.

Implication

Retrospective cohort study examines glucocorticoid impact on mortality in sepsis-related ARDS, suggesting treatment implications.

Abstract

In sepsis-associated ARDS, glucocorticoid selection and dose are associated with survival. Methylprednisolone and dexamethasone were associated with lower mortality compared to hydrocortisone, while high-dose therapy was linked to increased mortality.

Discussion

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69d896676c1944d70ce07cd6 https://doi.org/10.1097/shk.0000000000002815

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Association Between Different Glucocorticoids and Mortality in ICU Patients With Sepsis-related Acute Respiratory Distress Syndrome: A Retrospective cohort study from MIMIC-IV Database

Key Points

Implication

Abstract

Discussion

Cite This Study

Association Between Different Glucocorticoids and Mortality in ICU Patients With Sepsis-related Acute Respiratory Distress Syndrome: A Retrospective cohort study from MIMIC-IV Database

Key Points

Implication

Abstract

Discussion

Cite This Study

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