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April 10, 2026JAC-Antimicrobial ResistanceOpen Access

Characterizing β-lactam allergy prevalence among patients receiving infectious disease specialty care within a large US healthcare system in Washington

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Authors

KCKelly ColasJMJimmy MaKLKristine F Lan

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Overview

Cross-sectional study identifies prevalence of penicillin and cephalosporin allergies, suggesting need for improved delabelling strategies.

Key Points

  • The study aims to assess the prevalence of penicillin and cephalosporin allergy labels among patients receiving infectious disease specialty care.
  • Conducted a cross-sectional, retrospective cohort study.
  • Evaluated patients with penicillin or cephalosporin allergy labels in multiple outpatient and inpatient clinics.
  • Included adults over 18 years with allergy labels listed in electronic health records.
  • Found that 7.6%–16.7% of patients in outpatient clinics had penicillin allergy labels.
  • Reported hypersensitivity reactions in 62.9% of penicillin and 63.8% of cephalosporin allergy entries.
  • Only 7.8% of patients were referred to allergy specialists for delabelling.

Cite This Study

Colas et al. (2026) studied this question.

synapsesocial.com/papers/69d8967d6c1944d70ce07f69https://doi.org/10.1093/jacamr/dlag033
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Randomized Multicenter Trial for the Validation of an Easy-to-Administer Algorithm to Define Penicillin Allergy Status in Sexually Transmitted Infection Clinic Outpatients2024 · 8 citations
  2. 2Prevalence and characteristics of reported penicillin allergy in an urban outpatient adult population2014 · 167 citations
  3. 3Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy2023 · 199 citations
  4. 4Pharmacist-driven penicillin skin testing service for adults prescribed nonpreferred antibiotics in a community hospital2019 · 22 citations