A Robust [Pd(BIAN-IPr#)Cl2(H2O)] Catalyst Employing Water as a Disposable Ligand for C–S Cross Coupling of Aryl Chlorides and Thiols

Ziyi Quan; Zheng Wang; Yaxu Liu; Yuanchao Sun; Bo Wang

doi:10.1039/d6dt00623j

January 1, 2026Dalton Transactions

A Robust [Pd(BIAN-IPr#)Cl2(H2O)] Catalyst Employing Water as a Disposable Ligand for C–S Cross Coupling of Aryl Chlorides and Thiols

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Key Points

The study aims to develop a robust catalytic method for synthesizing aryl thioethers using water as a ligand.
Utilized a Pd(BIAN-IPr#)Cl2(H2O) catalyst.
Conducted cross-coupling reactions between aryl chlorides and thiols.
Employed water as a disposable ligand in the reaction.
Achieved high efficiency in the reaction conditions.
Successfully produced versatile aryl thioethers.
Demonstrated broad applicability across medicinal and agricultural chemistry.

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Implication

A novel protocol demonstrates effective C–S cross-coupling in aryl chlorides and thiols, suggesting practical synthesis methods.

Abstract

Aryl thioethers represent versatile synthetic intermediates with extensive applications spanning medicinal, biological, and agricultural chemistry. Herein, we report a highly efficient Pd-catalyzed cross-coupling protocol for the reaction of thiols with...

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Cite This Study

Quan et al. (2026) studied this question.

synapsesocial.com/papers/69d896a46c1944d70ce082a2 https://doi.org/10.1039/d6dt00623j

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A Robust [Pd(BIAN-IPr#)Cl2(H2O)] Catalyst Employing Water as a Disposable Ligand for C–S Cross Coupling of Aryl Chlorides and Thiols

Key Points

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Implication

Abstract

Discussion

Cite This Study

A Robust [Pd(BIAN-IPr#)Cl2(H2O)] Catalyst Employing Water as a Disposable Ligand for C–S Cross Coupling of Aryl Chlorides and Thiols

Key Points

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Implication

Abstract

Discussion

Cite This Study

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