Case report reveals skeletal metastases detection issues in medullary thyroid carcinoma, suggesting improved imaging methods.
A 78-year-old woman with medullary thyroid carcinoma (MTC) demonstrated persistently elevated serum calcitonin despite prior surgery and radiotherapy. 99m Tc-octreotide imaging failed to detect skeletal metastases, while 68 Ga-FAPI PET/CT revealed extensive skeletal involvement. Biochemical markers were disproportionately low relative to disease burden, consistent with a low-secretory MTC. This case highlights the limitations of SSTR-targeted imaging in MTC and underscores the diagnostic superiority of FAP-targeted imaging.
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Taheri et al. (2026) studied this question.
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