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April 10, 2026CellsOpen Access

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

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Authors

GBG BertoniUniversity of FlorenceSRSara RistoriUniversity of FlorenceDMDaniela MontiUniversity of Pisa

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Overview

A review synthesizes mechanisms linking immune aging to neurodegeneration, suggesting potential therapies for neurodegenerative diseases.

Key Points

  • This research aims to explore how immunosenescence and inflammaging contribute to neurodegenerative diseases.
  • Reviewed current literature on immune function alterations due to aging.
  • Analyzed the role of microglia and astrocytes in neuroinflammation.
  • Examined therapeutic strategies for restoring immune homeostasis.
  • Highlighted critical pathways linking immune dysregulation to neuronal loss.
  • Identified senolytics and microbiome-based interventions as promising therapies.
  • Discussed the impact of neuroinflammation on cognitive decline.

Cite This Study

Bertoni et al. (2026) studied this question.

synapsesocial.com/papers/69d896a46c1944d70ce0837bhttps://doi.org/10.3390/cells15080657
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