What question did this study set out to answer?

To determine whether endovascular treatment improves functional recovery and reduces mortality compared with best medical treatment alone in patients presenting with acute stroke caused by medium or distal vessel occlusions.

February 5, 2025New England Journal of MedicineOpen Access

Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels

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Authors

MPMarios‐Nikos PsychogiosUniversity of Messina ABAlex BrehmDefense Information Systems Agency MRMarc RibóHebron University

Discussion

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Implication

Randomized trial reveals no reduction in disability or death with endovascular therapy in medium or distal vessel stroke, suggesting medical treatment alone remains appropriate.

Key Points

To determine whether endovascular treatment improves functional recovery and reduces mortality compared with best medical treatment alone in patients presenting with acute stroke caused by medium or distal vessel occlusions.
Interventional clinical trial (DISTAL; ClinicalTrials.gov number, NCT05029414) comparing endovascular treatment against best medical therapy alone.
Evaluated patients experiencing acute stroke caused by occlusions of medium or distal cerebral vessels.
Endovascular treatment did not result in a lower level of post-stroke disability compared to best medical treatment alone (numerical effect estimates not reported in abstract).
Incidence of death was not reduced among patients undergoing endovascular treatment compared with standard medical management alone.

Cite This Study

Psychogios et al. (2025) studied this question.

synapsesocial.com/papers/69d898efde3177251abedaa5 https://doi.org/10.1056/nejmoa2408954

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Implication

Randomized trial reveals no reduction in disability or death with endovascular therapy in medium or distal vessel stroke, suggesting medical treatment alone remains appropriate.

Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels

Discussion

Member takes

Implication

Key Points

Cite This Study

Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels

Discussion

Member takes

Implication

Key Points

Cite This Study

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