What question did this study set out to answer?

To evaluate the feasibility and clinical utility of using multiplexed assays to identify oncogenic drivers and direct targeted therapies in patients with lung cancer.

May 20, 2014JAMA

Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

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To evaluate the feasibility and clinical utility of using multiplexed assays to identify oncogenic drivers and direct targeted therapies in patients with lung cancer.
Interventional clinical trial registered under clinicaltrials.gov identifier NCT01014286.
Tumor specimens were assessed with multiplexed assays to detect specific oncogenic driver alterations for targeted drug selection.
Multiplexed molecular profiling successfully enabled the identification of actionable oncogenic drivers to guide targeted drug therapy.
Specific numerical response rates, survival hazard ratios, and p-values are not reported in the trial registration summary.

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Implication

Randomized trial evaluates oncogenic driver testing to guide targeted therapy in lung cancer, highlighting biomarker-driven treatment strategies.

Abstract

clinicaltrials.gov Identifier: NCT01014286.

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Cite This Study

Kris et al. (2014) studied this question.

synapsesocial.com/papers/69d89acf18b0ca7f91d186c0 https://doi.org/10.1001/jama.2014.3741

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Implication

Randomized trial evaluates oncogenic driver testing to guide targeted therapy in lung cancer, highlighting biomarker-driven treatment strategies.

Abstract

clinicaltrials.gov Identifier: NCT01014286.

Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

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Abstract

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Cite This Study

Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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