April 1, 2002

Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors

Key Points

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Abstract

SSRI treatment of major depression is associated with increased occipital cortex GABA concentrations. This appears to result in a normalization of low pretreatment GABA concentrations, an effect that may contribute to a common mechanism of antidepressant action.

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Cite This Study

Sanacora et al. (Mon,) studied this question.

synapsesocial.com/papers/69d89b9652654bb436d197d5 https://doi.org/https://doi.org/10.1176/appi.ajp.159.4.663

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5Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies2000 · 133 citations

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