Vascular thrombosis after pediatric liver transplantation: Is prevention achievable?

Mercedes Martínez; Elise Kang; Fernando Beltramo; Michael Nares; Asumthia Jeyapalan; Alicia M. Alcamo; Alexandra Monde; Leslie Ridall; Sameer Kamath; Kristina Betters; Courtney M. Rowan; Richard S. Mangus; Shubhi Kaushik; Matt S. Zinter; Joseph Resch; Danielle Maue

doi:10.1016/j.liver.2023.100185

October 19, 2023Journal of Liver TransplantationOpen Access

Vascular thrombosis after pediatric liver transplantation: Is prevention achievable?

View Full Paper

Ask AI

Bookmark

Share

Key Points

To determine whether prophylactic anticoagulation prevents vascular thrombosis without increasing bleeding risk and to identify independent predictors of post-transplant thrombosis in pediatric liver recipients.
Analyzed clinical outcomes in a cohort of pediatric patients undergoing liver transplantation.
Assessed the safety of prophylactic anticoagulation by tracking post-operative bleeding complications.
Evaluated clinical and operative risk factors, including abdominal wall closure status, associated with vascular thrombosis.
Prophylactic anticoagulation did not cause an increase in post-transplant bleeding complications.
Open fascia closure, acting as a surrogate marker for graft-to-recipient size mismatch, was identified as the sole independent factor associated with vascular thrombosis.
Vascular thrombosis risk in this pediatric cohort appears driven by mechanical and surgical factors that anticoagulation therapy cannot overcome.

Implication

Cohort study reveals open fascia as an independent factor for vascular thrombosis in pediatric liver transplant recipients, suggesting surgical refinement rather than anticoagulation reduces risk.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Martínez et al. (2023) studied this question.

synapsesocial.com/papers/69d89dbaa5ecc596b5d17e7b https://doi.org/10.1016/j.liver.2023.100185

View Full Paper

Ask AI

Bookmark

Share

Vascular thrombosis after pediatric liver transplantation: Is prevention achievable?

Key Points

Implication

Discussion

Cite This Study

Vascular thrombosis after pediatric liver transplantation: Is prevention achievable?

Key Points

Implication

Discussion

Cite This Study

Keep reading

Keep reading