Does activation of eNOS and endothelial cells by insulin improve systemic bioenergetics and reduce atherosclerosis in obesity?
Endothelial dysfunction may be a major contributor to energy disequilibrium in obesity, as insulin-mediated activation of eNOS promotes brown fat differentiation and reduces atherosclerosis.
Activation of eNOS and endothelial cells by insulin enhanced the differentiation of PPC to BAT and its lipokines and improved systemic bioenergetics and atherosclerosis, suggesting that endothelial dysfunction is a major contributor of energy disequilibrium in obesity.
Park et al. (Wed,) studied this question.