Key result
Thermoneutral housing altered lipid profiles, increased aortic plaque size, and initiated atherosclerosis development in wild-type C57BL/6 mice.
Why the study?
Does thermoneutral housing combined with an obesogenic diet promote atherosclerosis in wild-type C57BL/6 mice?
Does thermoneutral housing combined with an obesogenic diet promote atherosclerosis in wild-type C57BL/6 mice?
Thermoneutral housing combined with an obesogenic diet successfully induces atherosclerosis in wild-type mice, providing a more physiologically relevant experimental model for studying the disease.
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Offers physiologically relevant atherosclerosis model in wild-type mice; leaves open human translation.
Giles et al. (2016) studied Atherosclerosis. Thermoneutral housing was evaluated on Development and progression of atherosclerosis. Thermoneutral housing altered lipid profiles, increased aortic plaque size, and initiated atherosclerosis development in wild-type C57BL/6 mice.
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