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August 23, 2011Heart

Central obesity and cardiovascular outcomes in patients with acute coronary syndrome: observations from the MERLIN-TIMI 36 trial

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Why the study?

Does central obesity increase the risk of adverse cardiovascular outcomes in patients with acute coronary syndrome?

Population

Patients with acute coronary syndrome (observations from the MERLIN-TIMI 36 trial)

Comparison

Central obesity vs Lack of central obesity

Design

Cohort

Authors

MKMitul B. KadakiaCFCaroline S. FoxBSBenjamin M. Scirica

Discussion

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Overview

May refine post-ACS risk stratification beyond BMI; hypothesis-generating and requires prospective validation.

Structured PICO

Does central obesity increase the risk of adverse cardiovascular outcomes in patients with acute coronary syndrome?

P
Population
Patients with acute coronary syndrome (observations from the MERLIN-TIMI 36 trial)
I
Intervention
Central obesity (waist circumference out of proportion to BMI)
C
Comparator
Lack of central obesity
O
Outcome
Cardiovascular outcomeshard clinical

Central adiposity, indicated by waist circumference out of proportion to BMI, may identify patients at highest risk for adverse cardiovascular outcomes following ACS, challenging the short-term obesity paradox.

Cite This Study

Kadakia et al. (2011) studied this question.

synapsesocial.com/papers/69d8a332a5ecc596b5d18070https://doi.org/10.1136/heartjnl-2011-300231
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