What question did this study set out to answer?

To establish a molecular mechanism explaining how constant hormonal or growth factor stimulation triggers periodic, transient calcium spikes rather than a sustained cytosolic increase.

July 1, 1988Proceedings of the National Academy of SciencesOpen Access

Molecular model for receptor-stimulated calcium spiking.

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Authors

TMTobias MeyerSemmelweis University LSLubert StryerStanford University

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Implication

Theoretical modeling study demonstrates periodic calcium spiking dynamics in hormone-stimulated cells, indicating a feedback mechanism for cellular signaling.

Key Points

To establish a molecular mechanism explaining how constant hormonal or growth factor stimulation triggers periodic, transient calcium spikes rather than a sustained cytosolic increase.
Formulated a kinetic molecular model incorporating crosscoupled signaling messengers, specifically inositol 1,4,5-trisphosphate (InsP3) and cytosolic calcium.
Integrated cooperative opening of endoplasmic reticulum channels, calcium-dependent activation of phospholipase C, mitochondrial calcium buffering, and Ca2+-ATPase pump kinetics.
Cooperative positive feedback between InsP3-gated channel opening and phospholipase C activation generates bistability, producing an abrupt cytosolic calcium surge upon reaching a threshold.
Mitochondrial calcium sequestration prevents excessive cytosolic accumulation and enables recovery, while the time required for Ca2+-ATPase pumps to refill the endoplasmic reticulum store dictates the inter-spike interval.
Calculated spike amplitudes, shapes, and oscillation periods match patterns documented in experimental observations.

Cite This Study

Meyer et al. (1988) studied this question.

synapsesocial.com/papers/69d8a3c28cb8f39931ae37bb https://doi.org/10.1073/pnas.85.14.5051

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Implication

Theoretical modeling study demonstrates periodic calcium spiking dynamics in hormone-stimulated cells, indicating a feedback mechanism for cellular signaling.

Molecular model for receptor-stimulated calcium spiking.

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Implication

Key Points

Cite This Study

Molecular model for receptor-stimulated calcium spiking.

Discussion

Member takes

Implication

Key Points

Cite This Study

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