Key result
Higher exercise dose shows a dose-dependent reduction in CVD risk factors and mortality.
Why the study?
There is wide variability in physical activity patterns among patients in contemporary cardiovascular clinical practice, necessitating a review of exercise dose impact on cardiovascular risk factors and mortality.
Supports dose-response benefits on CV risk factors and mortality; leaves open optimal individualized dosing in practice.
There is wide variability in the physical activity patterns of the patients in contemporary clinical cardiovascular practice. This review is designed to address the impact of exercise dose on key cardiovascular risk factors and on mortality. We begin by examining the body of literature that supports a dose-response relationship between exercise and cardiovascular disease risk factors, including plasma lipids, hypertension, diabetes mellitus, and obesity. We next explore the relationship between exercise dose and mortality by reviewing the relevant epidemiological literature underlying current physical activity guideline recommendations. We then expand this discussion to critically examine recent data pertaining to the impact of exercise dose at the lowest and highest ends of the spectrum. Finally, we provide a framework for how the key concepts of exercise dose can be integrated into clinical practice.
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Wasfy et al. (2016) conducted a review in Cardiovascular disease risk factors and mortality. Exercise dose was evaluated. Exercise dose demonstrates a dose-response relationship with cardiovascular disease risk factors and mortality, providing a framework for integration into clinical practice.
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