Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes

Areesha Moiz; Kristian B. Filion; Helia Toutounchi; Michael A. Tsoukas; Oriana Hoi Yun Yu; Tricia M. Peters; Mark J. Eisenberg

doi:10.7326/annals-24-01590

January 6, 2025Annals of Internal Medicine

Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes

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Key Points

To assess the efficacy and safety profile of glucagon-like peptide-1 receptor agonists for facilitating weight reduction in adults without diabetes mellitus.
Systematic review and meta-analysis protocol registered in PROSPERO (CRD42024505558).
Planned identification and synthesis of randomized controlled trials evaluating GLP-1 receptor agonists compared to placebo or active controls in non-diabetic adult populations.
Protocol established to quantify mean percent body weight change, proportion achieving target weight thresholds, and glycemic parameters.
Safety analyses pre-specified to evaluate the incidence and relative risk of gastrointestinal and serious adverse events across included trials.

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Implication

Systematic review protocol evaluates weight loss efficacy and safety of GLP-1 receptor agonists in adults without diabetes, highlighting clinical therapeutic utility.

Abstract

None. (PROSPERO: CRD42024505558).

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Moiz et al. (2025) studied this question.

synapsesocial.com/papers/69d8aa8518b0ca7f91d18c81 https://doi.org/10.7326/annals-24-01590

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Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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