Do body mass index, height, systolic blood pressure, and genetic liability to coronary artery disease causally affect the risk of atrial fibrillation?
This Mendelian randomization study provides genetic evidence that BMI, height, systolic blood pressure, and coronary artery disease are causal risk factors for atrial fibrillation, while identifying novel protein targets for potential therapy.
Our results suggest body mass index, height, systolic blood pressure and genetic liability to coronary artery disease are independent causal risk factors for AF. Several proteins, including DUSP13, IL-6R and TNFSF12, may have therapeutic potential for AF.
Wang et al. (Tue,) studied this question.